The Dinculesu Lab focuses on developing therapeutic approaches for Usher syndrome type 3, an autosomal recessive disorder, which leads to progressive retinal degeneration and hearing loss.

Dr Hauswirth has a long-term interest in the delivery and testing of potentially therapeutic genes for Dominant, Recessive and X-Linked Retinitis Pigmentosa, Leber Congenital Amaurosis, Achromatopsia, Blue Cone Monochromacy, Usher’s Disease, Macular Degeneration, Diabetic Retinopathy, Glaucoma and Optic Neuropathies in natural and transgenic animal models of each human disease.

Our research goal is to understand the pathogenesis of diabetic retinopathy and to develop more effective therapies for treatment of this condition, with a particular focus on the targeting ocular renin angiotensin system.

The principal focus of the Smith laboratory is on the molecular biochemistry and cell biology of the eye, with particular emphasis on the retina. The Smith Lab research has centered on canonical and non-canonical signaling pathways in photoreceptors, particularly focusing on the ancillary cascades signaled by the phototransduction elements.