Congratulations to Sean Crosson, Ph.D., Kaitlyn Calabro, and Russell Mellen for giving outstanding presentations at this year’s ASGCT meeting in Washington D.C.! Along with Dr. Boye, they rounded out 4 oral presentations at this year’s conference. Dr. Boye discussed her team’s efforts to develop novel AAV capsids that exhibit…
K. Tyler McCullough successfully defended his Ph.D. thesis on March 25th, 2019! We are excited that Tyler decided to join grad school (aka come to the ‘dark side’), and to conduct his studies in the Boye Lab. For the experience he brought with him, he was the program’s first ‘fast-track’…
As if loving what you do for a living wasn’t enough, today I received a beautiful bouquet of flowers from a grateful patient all the way in Denmark. Thank you so much to Klaus and little Rasmus for this incredibly generous and unexpected surprise! This happens so infrequently in…
Genome-editing technologies that correct specific mutations represent a transformative new approach for treating genetic disorders. Despite its widespread use in mouse models of disease, and in cell lines, the Boye lab was the first to demonstrate the effects of CRISPR/Cas9 mediated gene editing in somatic cells of non-human primate. Their…
Doctoral candidate Kaitlyn Calabro had the pleasure of presenting her work this week at the Retinal Degeneration meeting in Ireland. She summarized her efforts to characterize a novel mouse model of Usher syndrome 1B and the effects of dual AAV-MYO7A vectors in these mice and in macaque. She fits right…
The 2018 Antonio Champalimaud Vision Award recognizes Hauswirth and his colleagues for developing the first successful gene therapy to cure an inherited human disease. The disease, Leber congenital amaurosis Type 2, or LCA 2, is caused by a genetic defect. The 1 million euro (approximately $1.2 million) award from the Portugal-based…
“When you get where you’re goin’, don’t forget turn back around. Help the next one in line. Always stay humble and kind”. These lyrics from Tim McGraw (yes, I like him, so what?!) remind me of Mavis Agbandje-McKenna. She is the queen of AAV… she’s basically the queen of gene…
Kaitlyn Calabro, doctoral candidate in Dr. Boye’s lab, was recently awarded a Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship. The overall goal of Kaitlyn’s proposal, “Exploring MYO7A function in novel mouse models and improving AAV-Dual Vector Gene Therapy for Usher Syndrome 1B” is to generate…
The Boye Lab congratulates its newest doctoral candidate, Tyler McCullough! He passed his qualifying exam with flying colors and is slated to fast track to graduation! Congrats Tyler! Additional congrats are in order for his first paper presentation at an international conference (ARVO, Honolulu 2018)!…
We welcome everyone to come hear our talks/visit our posters at this year’s Retinal Cell and Gene Therapy Innovation Summit, ARVO and ASGCT meetings. Below is a list of all the Boye Lab projects being presented: “Identification of AAV capsid variants with enhanced retinal transduction following screening in non-human primate”.
