Frank M Dyka

Frank M Dyka,

Assistant Scientist

Department: MD-OPHTHALMOLOGY
Business Phone: (352) 273-8788
Business Email: fmdyka@ufl.edu

Publications

2021
Disease mechanisms of X-linked cone dystrophy caused by missense mutations in the red and green cone opsins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35(10) [DOI] 10.1096/fj.202101066R. [PMID] 34547123.
2020
Clarin-1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome.
The Journal of pathology. 250(2):195-204 [DOI] 10.1002/path.5360. [PMID] 31625146.
2019
Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model.
Proceedings of the National Academy of Sciences of the United States of America. 116(10):4496-4501 [DOI] 10.1073/pnas.1817537116. [PMID] 30782832.
2019
Dual ABCA4-AAV Vector Treatment Reduces Pathogenic Retinal A2E Accumulation in a Mouse Model of Autosomal Recessive Stargardt Disease.
Human gene therapy. 30(11):1361-1370 [DOI] 10.1089/hum.2019.132. [PMID] 31418294.
2018
Co-Expression of Wild-Type and Mutant S163R C1QTNF5 in Retinal Pigment Epithelium.
Advances in experimental medicine and biology. 1074:61-66 [DOI] 10.1007/978-3-319-75402-4_8. [PMID] 29721928.
2016
AAV-Mediated Clarin-1 Expression in the Mouse Retina: Implications for USH3A Gene Therapy.
PloS one. 11(2) [DOI] 10.1371/journal.pone.0148874. [PMID] 26881841.
2015
Intravitreal Delivery of a Novel AAV Vector Targets on Bipolar Cells and Restores Visual Function in a Mouse Model of Complete Congenital Stationary Night Blindness
Human Molecular Genetics. 24(21):6229-6239 [DOI] 10.1093/hmg/ddv341. [PMID] 26310623.
2015
Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium.
Investigative ophthalmology & visual science. 56(11):6971-80 [DOI] 10.1167/iovs.15-17166. [PMID] 26513502.
2015
Stability and Safety of an AAV Vector for Treating RPGR-ORF15 X-Linked Retinitis Pigmentosa.
Human gene therapy. 26(9):593-602 [DOI] 10.1089/hum.2015.035. [PMID] 26076799.
2014
Cone specific promoter for use in gene therapy of retinal degenerative diseases.
Advances in experimental medicine and biology. 801:695-701 [DOI] 10.1007/978-1-4614-3209-8_87. [PMID] 24664760.
2014
Dual adeno-associated virus vectors result in efficient in vitro and in vivo expression of an oversized gene, MYO7A.
Human gene therapy methods. 25(2):166-77 [DOI] 10.1089/hgtb.2013.212. [PMID] 24568220.
2014
Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors.
Molecular therapy. Methods & clinical development. 1 [PMID] 24761428.
View on: PubMed
2013
AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis.
Human gene therapy. 24(2):189-202 [DOI] 10.1089/hum.2012.193. [PMID] 23210611.
2013
Cholesterol transport via ABCA1: new insights from solid-phase binding assay.
Biochimie. 95(4):957-61 [DOI] 10.1016/j.biochi.2012.11.009. [PMID] 23201557.
2013
Dual Adeno-Associated Virus Vectors for Delivery of Large Genes To the Retina
Molecular Therapy. 21:S86-S87
2013
New Minipromoters With Restricted-Retinal Expression When Docked in the Mouse Genome Show the Same Expression When Delivered in Aav
Molecular Therapy. 21:S47-S48
2013
Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus.
Gene therapy. 20(8):824-33 [DOI] 10.1038/gt.2013.3. [PMID] 23344065.
2013
Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.
PloS one. 8(4) [DOI] 10.1371/journal.pone.0062097. [PMID] 23637972.
2011
Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse.
Investigative ophthalmology & visual science. 52(10):7098-108 [DOI] 10.1167/iovs.11-7867. [PMID] 21778276.
2010
Interaction and localization of the retinitis pigmentosa protein RP2 and NSF in retinal photoreceptor cells.
Biochemistry. 49(35):7439-47 [DOI] 10.1021/bi1005249. [PMID] 20669900.
2009
Relation of response to treatment with dorzolamide in X-linked retinoschisis to the mechanism of functional loss in retinoschisin.
American journal of ophthalmology. 147(1):111-115.e1 [DOI] 10.1016/j.ajo.2008.07.041. [PMID] 18834580.
2008
Characterization and purification of the discoidin domain-containing protein retinoschisin and its interaction with galactose.
Biochemistry. 47(35):9098-106 [DOI] 10.1021/bi800938g. [PMID] 18690710.
2007
Coexpression and interaction of wild-type and missense RS1 mutants associated with X-linked retinoschisis: its relevance to gene therapy.
Investigative ophthalmology & visual science. 48(6):2491-7 [PMID] 17525175.
View on: PubMed
2006
An unusual X-linked retinoschisis phenotype and biochemical characterization of the W112C RS1 mutation.
Vision research. 46(22):3845-52 [PMID] 16884758.
View on: PubMed
2005
Subunits of the epithelial sodium channel family are differentially expressed in the retina of mice with ocular hypertension.
Journal of neurochemistry. 94(1):120-8 [PMID] 15953355.
View on: PubMed
2004
Metabotropic glutamate receptors are differentially regulated under elevated intraocular pressure.
Journal of neurochemistry. 90(1):190-202 [PMID] 15198678.
View on: PubMed
2001
Transcription of glycolytic genes and operons in Bacillus subtilis: evidence for the presence of multiple levels of control of the gapA operon.
Molecular microbiology. 41(2):409-22 [PMID] 11489127.
View on: PubMed

Grants

Jul 2021 ACTIVE
Production of condensed scAAV vectors for adRP
Role: Principal Investigator
Funding: IVERIC BIO
Oct 2020 – Mar 2021
Production of a Lentivirus RHO-GFP Vector
Role: Principal Investigator
Funding: IVERIC BIO
Jan 2019 – Dec 2019
Dual Vectors for Otoferlin
Role: Co-Investigator
Funding: DECIBEL THERAPEUTICS

Patents

Issued June 2016
Chimeric Promoter for Cone Photoreceptor Targeted Gene Therapy
#9,375,491
Published February 2015
Methods and Compositions for Gene Delivery to On Bipolar Cells
#US2017/0007720
Published May 2014
Dual-AAV Vector-Based Systems and Methods for Delivering Oversized Genes to Mammalian Cells
#US2014/0256802

Contact Details

Phones:
Business:
(352) 273-8788
Emails:
Business:
fmdyka@ufl.edu