Cristhian J Ildefonso, PhD
Assistant Professor
Teaching Profile
Courses Taught
2018,2020-2023,2023-2024
GMS6791 Visual Neuroscience Journal Club
2017
GMS6709 Current Topics in Vision
2023-2024
BMS6003 Genetics and Health
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-6179-720X
Publications
2023
Binocular benefit following monocular subretinal AAV injection in a mouse model of autosomal dominant retinitis pigmentosa (adRP).
Vision research.
206
[DOI] 10.1016/j.visres.2023.108189.
[PMID] 36773475.
2023
Modulation of Retinal Inflammation Delays Degeneration in a Mouse Model of Geographic Atrophy.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.02.08.527757.
[PMID] 36798403.
2023
Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness
Science Advances.
9(28)
[DOI] 10.1126/sciadv.add5479.
[PMID] 37450596.
2023
Suppressor of cytokine signaling 3-derived peptide as a therapeutic for inflammatory and oxidative stress-induced damage to the retina.
Molecular vision.
29:338-356
[PMID] 38264613.
2022
Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
38(5):359-371
[DOI] 10.1089/jop.2022.0002.
[PMID] 35446130.
2021
Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis.
Translational vision science & technology.
10(3)
[DOI] 10.1167/tvst.10.3.25.
[PMID] 34003962.
2021
Molecular Design and Production of AAV Viral Vectors for Gene Therapy.
Methods in molecular biology (Clifton, N.J.).
2225:77-92
[DOI] 10.1007/978-1-0716-1012-1_5.
[PMID] 33108658.
2020
A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis.
PloS one.
15(2)
[DOI] 10.1371/journal.pone.0227524.
[PMID] 32101556.
2020
Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics.
Journal of clinical medicine.
9(4)
[DOI] 10.3390/jcm9040972.
[PMID] 32244484.
2020
Inhibitors of metalloprotease, γ-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication
PLOS ONE.
15(7)
[DOI] 10.1371/journal.pone.0236175.
[PMID] 32697798.
2020
Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-73749-y.
[PMID] 33046772.
2019
AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis
Journal of Clinical Medicine.
8(12)
[DOI] 10.3390/jcm8122082.
[PMID] 31795515.
2019
Co-Delivery of a Short-Hairpin RNA and a shRNA-Resistant Replacement Gene with Adeno-Associated Virus: An Allele-Independent Strategy for Autosomal-Dominant Retinal Disorders.
Methods in molecular biology (Clifton, N.J.).
1937:235-258
[DOI] 10.1007/978-1-4939-9065-8_15.
[PMID] 30706401.
2019
Expression of a CARD Slows the Retinal Degeneration of a Geographic Atrophy Mouse Model.
Molecular therapy. Methods & clinical development.
14:113-125
[DOI] 10.1016/j.omtm.2019.06.001.
[PMID] 31334304.
2019
Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors.
Redox biology.
24
[DOI] 10.1016/j.redox.2019.101201.
[PMID] 31039480.
2019
Systematic Injection of Low-Dose LPS Transiently Improves the Retina Function and Structure of a Mouse Model of Geographic Atrophy.
Advances in experimental medicine and biology.
1185:57-62
[DOI] 10.1007/978-3-030-27378-1_10.
[PMID] 31884589.
2018
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis
Experimental Eye Research.
177:12-22
[DOI] 10.1016/j.exer.2018.07.020.
[PMID] 30048621.
2018
Adeno-Associated Virus Delivery of Viral Serpins for Ocular Diseases: Design and Validation.
Methods in molecular biology (Clifton, N.J.).
1826:237-254
[DOI] 10.1007/978-1-4939-8645-3_16.
[PMID] 30194605.
2018
Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa.
Investigative ophthalmology & visual science.
59(13):5417-5430
[DOI] 10.1167/iovs.18-25345.
[PMID] 30452595.
2018
Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview.
Advances in experimental medicine and biology.
1074:185-191
[DOI] 10.1007/978-3-319-75402-4_23.
[PMID] 29721943.
2017
Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD.
Investigative ophthalmology & visual science.
58(2):1237-1245
[DOI] 10.1167/iovs.16-21272.
[PMID] 28241311.
2016
Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.
Advances in experimental medicine and biology.
854:31-7
[DOI] 10.1007/978-3-319-17121-0_5.
[PMID] 26427390.
2016
Repurposing an orally available drug for the treatment of geographic atrophy.
Molecular vision.
22:294-310
[PMID] 27110092.
2016
Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide.
Investigative ophthalmology & visual science.
57(2):372-86
[DOI] 10.1167/iovs.15-17703.
[PMID] 26842755.
2016
The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration.
Advances in experimental medicine and biology.
854:59-65
[DOI] 10.1007/978-3-319-17121-0_9.
[PMID] 26427394.
2015
Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation.
Human gene therapy.
26(1):59-68
[DOI] 10.1089/hum.2014.089.
[PMID] 25420215.
2015
Gene therapy with the caspase activation and recruitment domain reduces the ocular inflammatory response.
Molecular therapy : the journal of the American Society of Gene Therapy.
23(5):875-884
[DOI] 10.1038/mt.2015.30.
[PMID] 25698151.
2015
Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress.
Experimental eye research.
140:94-105
[DOI] 10.1016/j.exer.2015.07.022.
[PMID] 26315784.
2014
Systematic review and meta-analysis of the association between complement factor H I62V polymorphism and risk of polypoidal choroidal vasculopathy in Asian populations.
PloS one.
9(2)
[DOI] 10.1371/journal.pone.0088324.
[PMID] 24520367.
2012
The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression.
The Journal of biological chemistry.
287(39):32697-707
[PMID] 22865879.
2010
Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma.
Molecular therapy : the journal of the American Society of Gene Therapy.
18(10):1885-90
[DOI] 10.1038/mt.2010.139.
[PMID] 20606647.
2006
Altered subcellular signaling in murine peritoneal macrophages upon chronic morphine exposure.
Journal of neuroimmunology.
176(1-2):86-94
[PMID] 16750574.
Grants
Jul 2019
– Jul 2022
Gene Therapy for Bestrophinopathies – Silent and Replace BEST
Role: Principal Investigator
Funding: IVERIC BIO
Jul 2017
– Sep 2019
Local and Systemic Inflammation in a Mouse Model of RPE-oxidative Damage
Role: Principal Investigator
Funding: BRIGHTFOCUS FOU
Aug 2016
– Jul 2022
Testing Gene Therapy in Models of Geographic Atrophy
Role: Faculty
Funding: NATL INST OF HLTH NEI
Education
Ph.D.
2005-2011
·
Baylor College of Medicine
B.Sc.
1999-2005
·
University of Puerto Rico – San Juan
Contact Details
Phones:
- Business:
- (352) 273-8786
Emails:
- Business:
- ildefons@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100284
GAINESVILLE FL 32610 - Business Street:
-
1395 CENTER DR HSC RM M-119
GAINESVILLE FL 326100001