Cristhian J Ildefonso

Cristhian J Ildefonso,

Assistant Professor

Department: MD-OPHTHALMOLOGY
Business Phone: (352) 273-8786
Business Email: ildefons@ufl.edu

Publications

2021
Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis.
Translational vision science & technology. 10(3) [DOI] 10.1167/tvst.10.3.25. [PMID] 34003962.
2021
Molecular Design and Production of AAV Viral Vectors for Gene Therapy.
Methods in molecular biology (Clifton, N.J.). 2225:77-92 [DOI] 10.1007/978-1-0716-1012-1_5. [PMID] 33108658.
2020
A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis.
PloS one. 15(2) [DOI] 10.1371/journal.pone.0227524. [PMID] 32101556.
2020
Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics.
Journal of clinical medicine. 9(4) [DOI] 10.3390/jcm9040972. [PMID] 32244484.
2020
Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-73749-y. [PMID] 33046772.
2019
AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis.
Journal of clinical medicine. 8(12) [DOI] 10.3390/jcm8122082. [PMID] 31795515.
2019
Co-Delivery of a Short-Hairpin RNA and a shRNA-Resistant Replacement Gene with Adeno-Associated Virus: An Allele-Independent Strategy for Autosomal-Dominant Retinal Disorders.
Methods in molecular biology (Clifton, N.J.). 1937:235-258 [DOI] 10.1007/978-1-4939-9065-8_15. [PMID] 30706401.
2019
Expression of a CARD Slows the Retinal Degeneration of a Geographic Atrophy Mouse Model.
Molecular therapy. Methods & clinical development. 14:113-125 [DOI] 10.1016/j.omtm.2019.06.001. [PMID] 31334304.
2019
Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors.
Redox biology. 24 [DOI] 10.1016/j.redox.2019.101201. [PMID] 31039480.
2019
Systematic Injection of Low-Dose LPS Transiently Improves the Retina Function and Structure of a Mouse Model of Geographic Atrophy.
Advances in experimental medicine and biology. 1185:57-62 [DOI] 10.1007/978-3-030-27378-1_10. [PMID] 31884589.
2018
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis.
Experimental eye research. 177:12-22 [DOI] 10.1016/j.exer.2018.07.020. [PMID] 30048621.
2018
Adeno-Associated Virus Delivery of Viral Serpins for Ocular Diseases: Design and Validation.
Methods in molecular biology (Clifton, N.J.). 1826:237-254 [DOI] 10.1007/978-1-4939-8645-3_16. [PMID] 30194605.
2018
Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa.
Investigative ophthalmology & visual science. 59(13):5417-5430 [DOI] 10.1167/iovs.18-25345. [PMID] 30452595.
2018
Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview.
Advances in experimental medicine and biology. 1074:185-191 [DOI] 10.1007/978-3-319-75402-4_23. [PMID] 29721943.
2017
Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD.
Investigative ophthalmology & visual science. 58(2):1237-1245 [DOI] 10.1167/iovs.16-21272. [PMID] 28241311.
2016
Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.
Advances in experimental medicine and biology. 854:31-7 [DOI] 10.1007/978-3-319-17121-0_5. [PMID] 26427390.
2016
Repurposing an orally available drug for the treatment of geographic atrophy.
Molecular vision. 22:294-310 [PMID] 27110092.
View on: PubMed
2016
Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide.
Investigative ophthalmology & visual science. 57(2):372-86 [DOI] 10.1167/iovs.15-17703. [PMID] 26842755.
2016
The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration.
Advances in experimental medicine and biology. 854:59-65 [DOI] 10.1007/978-3-319-17121-0_9. [PMID] 26427394.
2015
Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation.
Human gene therapy. 26(1):59-68 [DOI] 10.1089/hum.2014.089. [PMID] 25420215.
2015
Gene therapy with the caspase activation and recruitment domain reduces the ocular inflammatory response.
Molecular therapy : the journal of the American Society of Gene Therapy. 23(5):875-884 [DOI] 10.1038/mt.2015.30. [PMID] 25698151.
2015
Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress.
Experimental eye research. 140:94-105 [DOI] 10.1016/j.exer.2015.07.022. [PMID] 26315784.
2014
Systematic review and meta-analysis of the association between complement factor H I62V polymorphism and risk of polypoidal choroidal vasculopathy in Asian populations.
PloS one. 9(2) [DOI] 10.1371/journal.pone.0088324. [PMID] 24520367.
2012
The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression.
The Journal of biological chemistry. 287(39):32697-707 [PMID] 22865879.
View on: PubMed
2010
Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma.
Molecular therapy : the journal of the American Society of Gene Therapy. 18(10):1885-90 [DOI] 10.1038/mt.2010.139. [PMID] 20606647.
2006
Altered subcellular signaling in murine peritoneal macrophages upon chronic morphine exposure.
Journal of neuroimmunology. 176(1-2):86-94 [PMID] 16750574.
View on: PubMed

Grants

Jul 2019 ACTIVE
Gene Therapy for Bestrophinopathies – Silent and Replace BEST
Role: Principal Investigator
Funding: IVERIC BIO
Jul 2017 – Sep 2019
Local and Systemic Inflammation in a Mouse Model of RPE-oxidative Damage
Role: Principal Investigator
Funding: BRIGHTFOCUS FOU
Aug 2016 ACTIVE
Testing Gene Therapy in Models of Geographic Atrophy
Role: Faculty
Funding: NATL INST OF HLTH NEI

Patents

Published March 2015
Use Of Aav-Expressed M013 Protein As An Anti-Inflammatory Therapeutic
#US2016/0376325
Published February 2015
Delivery of NRF2 as Therapy for Protection Against Reactive Oxygen Species
#US2017/0088593
Published March 2014
Anti-Inflammatory AAV Vector Targeting Inflammasome Mediated Activation of Caspase-1
#US-2016-0017012

Teaching Profile

Courses Taught
2018,2020-2021
GMS6791 Visual Neuroscience Journal Club
2017
GMS6709 Current Topics in Vision

Contact Details

Phones:
Business:
(352) 273-8786
Emails:
Business:
ildefons@ufl.edu