Qiuhong Li

Qiuhong Li,

Associate Professor

Department: MD-OPHTHALMOLOGY
Business Phone: (352) 273-7540
Business Email: qli@ufl.edu

Publications

2020
ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2.
Hypertension (Dallas, Tex. : 1979). 76(3):651-661 [DOI] 10.1161/HYPERTENSIONAHA.120.15595. [PMID] 32783758.
2020
ACE2 as therapeutic agent.
Clinical science (London, England : 1979). 134(19):2581-2595 [DOI] 10.1042/CS20200570. [PMID] 33063820.
2020
Angiotensin (1-7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older rats.
GeroScience. 42(5):1307-1321 [DOI] 10.1007/s11357-020-00196-y. [PMID] 32451847.
2020
Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
Molecular neurobiology. 57(1):513-527 [DOI] 10.1007/s12035-019-01716-4. [PMID] 31392515.
2020
Therapeutic Delivery of Ang(1-7) via Genetically Modified Probiotic: A Dosing Study.
The journals of gerontology. Series A, Biological sciences and medical sciences. 75(7):1299-1303 [DOI] 10.1093/gerona/glz222. [PMID] 31586210.
2019
Impact of gut microbiota structure in heat-stressed broilers.
Poultry science. 98(6):2405-2413 [DOI] 10.3382/ps/pez026. [PMID] 30715508.
2019
Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat.
Gene therapy. 26(12):479-490 [DOI] 10.1038/s41434-019-0100-9. [PMID] 31562387.
2018
Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.
Diabetes. 67(9):1867-1879 [DOI] 10.2337/db18-0158. [PMID] 29712667.
2017
A Novel Bispecific Molecule Delivered By Recombinant Aav2 Suppresses Ocular Inflammation and Choroidal Neovascularization
Journal of Cellular and Molecular Medicine. 21(8):1555-1571 [DOI] 10.1111/jcmm.13086. [PMID] 28332318.
2017
Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-03397-2. [PMID] 28607377.
2016
Aav-Mediated Clarin-1 Expression in the Mouse Retina: Implications for Ush3a Gene Therapy
PLoS One. 11(2) [DOI] 10.1371/journal.pone.0148874. [PMID] 26881841.
2016
Aav8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis By Regulating Mapk, Nf-Kappa B and Stat3 Pathways
Scientific Reports. 6 [DOI] 10.1038/srep31912. [PMID] 27558087.
2016
Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice
The American Journal Of Pathology. 186(6):1688-1700 [DOI] 10.1016/j.ajpath.2016.01.023. [PMID] 27178803.
2016
Beneficial Effects of Combined At(1) Receptor/Neprilysin Inhibition (Arni) Versus At(1) Receptor Blockade Alone in the Diabetic Eye
Investigative Ophthalmology & Visual Science. 57(15):6722-6730 [DOI] 10.1167/iovs.16-20289. [PMID] 27951594.
2015
Downregulating p22phox ameliorates inflammatory response in Angiotensin II-induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells.
Scientific reports. 5 [DOI] 10.1038/srep14362. [PMID] 26415877.
2015
Gene Delivery of a Viral Anti-Inflammatory Protein To Combat Ocular Inflammation
Human Gene Therapy. 26(1):59-68 [DOI] 10.1089/hum.2014.089. [PMID] 25420215.
2015
Gene therapy with the caspase activation and recruitment domain reduces the ocular inflammatory response.
Molecular therapy : the journal of the American Society of Gene Therapy. 23(5):875-884 [DOI] 10.1038/mt.2015.30. [PMID] 25698151.
2014
Combined Renin Inhibition/(Pro)Renin Receptor Blockade in Diabetic Retinopathy- a Study in Transgenic (Mren2)27 Rats
PLoS One. 9(6) [DOI] 10.1371/journal.pone.0100954. [PMID] 24968134.
2014
Gene therapy in the rd6 mouse model of retinal degeneration.
Advances in experimental medicine and biology. 801:711-8 [DOI] 10.1007/978-1-4614-3209-8_89. [PMID] 24664762.
2014
Ocular Endoplasmic Reticulum Stress and Inflammation Is Attenuated By Supplementation With Muscadine Grape Polyphenols in Vitro and in Vivo
The FASEB's Journal. 28(1, S)
2014
Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice.
The Journal of nutrition. 144(6):799-806 [DOI] 10.3945/jn.113.186957. [PMID] 24699803.
2014
Oral delivery of ACE2/Ang-(1-7) bioencapsulated in plant cells protects against experimental uveitis and autoimmune uveoretinitis.
Molecular therapy : the journal of the American Society of Gene Therapy. 22(12):2069-2082 [DOI] 10.1038/mt.2014.179. [PMID] 25228068.
2014
Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.
Hypertension (Dallas, Tex. : 1979). 64(6):1248-59 [DOI] 10.1161/HYPERTENSIONAHA.114.03871. [PMID] 25225206.
2014
Oral Delivery of Bioencapsulated Proteins Across Blood-Brain and Blood-Retinal Barriers
Molecular Therapy. 22(3):535-546 [DOI] 10.1038/mt.2013.273. [PMID] 24281246.
2014
STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models.
Proceedings of the National Academy of Sciences of the United States of America. 111(52):E5716-23 [DOI] 10.1073/pnas.1411248112. [PMID] 25512545.
2013
Chronic Knockdown of the Nucleus of the Solitary Tract At(1) Receptors Increases Blood Inflammatory-Endothelial Progenitor Cell Ratio and Exacerbates Hypertension in the Spontaneously Hypertensive Rat
Hypertension. 61(6):1328-U415 [DOI] 10.1161/HYPERTENSIONAHA.111.00156. [PMID] 23547238.
2013
Expression of Adiponectin and Its Receptors in Type 1 Diabetes Mellitus in Human and Mouse Retinas
Molecular Vision. 19:1769-1778
2013
Nucleus of the solitary tract (pro)renin receptor-mediated antihypertensive effect involves nuclear factor-κB-cytokine signaling in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979). 61(3):622-7 [DOI] 10.1161/HYPERTENSIONAHA.111.199836. [PMID] 23319541.
2012
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy.
Molecular therapy : the journal of the American Society of Gene Therapy. 20(1):28-36 [DOI] 10.1038/mt.2011.155. [PMID] 21792177.
2012
Aqueous humor and plasma adiponectin levels in proliferative diabetic retinopathy patients.
Current eye research. 37(9):803-8 [DOI] 10.3109/02713683.2012.676700. [PMID] 22563689.
2012
Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept.
Human gene therapy. 23(4):367-76 [DOI] 10.1089/hum.2011.169. [PMID] 22142163.
2012
Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes.
Diabetes. 61(12):3270-9 [DOI] 10.2337/db11-1596. [PMID] 22891211.
2012
Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury.
Experimental physiology. 97(1):89-101 [DOI] 10.1113/expphysiol.2011.060673. [PMID] 21967903.
2012
Nts (Pro)Renin Receptor (Prr)-Mediated Antihypertensive Effect Involves Nf-Kappab-Cytokine Signaling in the Spontaneously Hypertensive Rats (Shr)
The FASEB's Journal. 26
2012
Tyrosine-Mutant Aav8 Delivery of Human Mertk Provides Long-Term Retinal Preservation in Rcs Rats
Investigative Ophthalmology & Visual Science. 53(4):1895-1904 [DOI] 10.1167/iovs.11-8831. [PMID] 22408006.
2011
(Pro)Renin Receptor (Prr) Mediates Antihypertensive Effects in the Necleus of Solitary Tract (Nts) of Spontaneously Hypertensive Rats (Shr)
Hypertension. 58
2011
Ab-externo AAV-mediated gene delivery to the suprachoroidal space using a 250 micron flexible microcatheter.
PloS one. 6(2) [DOI] 10.1371/journal.pone.0017140. [PMID] 21347253.
2011
Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells.
Investigative ophthalmology & visual science. 52(8):5093-104 [DOI] 10.1167/iovs.10-70911. [PMID] 21676908.
2011
Endothelial dysfunction as a potential contributor in diabetic nephropathy.
Nature reviews. Nephrology. 7(1):36-44 [DOI] 10.1038/nrneph.2010.152. [PMID] 21045790.
2011
Inhibition of Choroidal Neovascularization in a Nonhuman Primate Model By Intravitreal Administration of An Aav2 Vector Expressing a Novel Anti-Vegf Molecule
Molecular Therapy. 19(2):260-265 [DOI] 10.1038/mt.2010.230. [PMID] 20978476.
2011
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina.
Molecular therapy : the journal of the American Society of Gene Therapy. 19(2):293-301 [DOI] 10.1038/mt.2010.234. [PMID] 21045809.
2011
Selective stimulation of VEGFR2 accelerates progressive renal disease.
The American journal of pathology. 179(1):155-66 [DOI] 10.1016/j.ajpath.2011.03.024. [PMID] 21640973.
2010
Achromatopsia as a Potential Candidate for Gene Therapy
Advances in experimental medicine and biology. 664:639-646 [DOI] 10.1007/978-1-4419-1399-9\_73. [PMID] 20238068.
2010
Diabetic eNOS-knockout mice develop accelerated retinopathy.
Investigative ophthalmology & visual science. 51(10):5240-6 [DOI] 10.1167/iovs.09-5147. [PMID] 20435587.
2010
Involvement of the brain (pro)renin receptor in cardiovascular homeostasis.
Circulation research. 107(7):934-8 [DOI] 10.1161/CIRCRESAHA.110.226977. [PMID] 20689062.
2010
Is (pro)renin receptor a multifunctional receptor?
Hypertension (Dallas, Tex. : 1979). 55(6):1308-9 [DOI] 10.1161/HYPERTENSIONAHA.110.151142. [PMID] 20368502.
2010
Selective tropism of the recombinant adeno-associated virus 9 serotype for rat cardiac tissue.
The journal of gene medicine. 12(1):22-34 [DOI] 10.1002/jgm.1404. [PMID] 19830780.
2010
Soluble Flt-1 Gene Therapy Ameliorates Albuminuria But Accelerates Tubulointerstitial Injury in Diabetic Mice
American Journal of Physiology-Renal Physiology. 298(3):F609-F616 [DOI] 10.1152/ajprenal.00377.2009. [PMID] 20015944.
2009
Dose-Dependent Humoral Immune Responses To Intravitreal Delivery of Aav Vectors and Strategies To Circumvent
Molecular Therapy. 17
2009
Gene Therapy Following Subretinal Aav5 Vector Delivery Is Not Affected By a Previous Intravitreal Aav5 Vector Administration in the Partner Eye
Molecular Vision. 15:267-275
2009
Gene therapy for red-green colour blindness in adult primates.
Nature. 461(7265):784-7 [DOI] 10.1038/nature08401. [PMID] 19759534.
2009
High-Efficiency Transduction of the Mouse Retina By Tyrosine-Mutant Aav Serotype Vectors
Molecular Therapy. 17(3):463-471 [DOI] 10.1038/mt.2008.269. [PMID] 19066593.
2009
Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, But Not Tubulointerstitial Injury, in Diabetic Enos Knockout Mice
The American Journal Of Pathology. 174(4):1221-1229 [DOI] 10.2353/ajpath.2009.080605. [PMID] 19246639.
2008
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.
Investigative Ophthalmology & Visual Science. 49(10):4278-83 [DOI] 10.1167/iovs.07-1622. [PMID] 18586879.
2008
Comparative Analysis of in Vivo and in Vitro Aav Vector Transduction in the Neonatal Mouse Retina: Effects of Serotype and Site of Administration
Vision Research. 48(3):377-385 [DOI] 10.1016/j.visres.2007.08.009. [PMID] 17950399.
2008
Cone-Specific Expression Using a Human Red Opsin Promoter in Recombinant Aav
Vision Research. 48(3):332-338 [DOI] 10.1016/j.visres.2007.07.026. [PMID] 17905404.
2008
Downregulation of P22Phox in Retinal Pigment Epithelial Cells Inhibits Choroidal Neovascularization in Mice
Molecular Therapy. 16(10):1688-1694 [DOI] 10.1038/mt.2008.164. [PMID] 18665154.
2008
Intraocular Route of Aav2 Vector Administration Defines Humoral Immune Response and Therapeutic Potential
Molecular Vision. 14:1760-1769
2008
Intraocular Route of Aav2 Vector Administration Defines Humoral Immune Response and Therapeutic Potential
Molecular Vision. 14:1760-1769
2008
Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential.
Molecular Vision. 14:1760-9 [PMID] 18836574.
View on: PubMed
2007
Restoration of cone vision in a mouse model of achromatopsia.
Nature medicine. 13(6):685-7 [PMID] 17515894.
View on: PubMed
2006
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.
Molecular Therapy. 13(3):565-72 [DOI] 10.1016/j.ymthe.2005.09.001. [PMID] 16223604.
2001
Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse.
Investigative ophthalmology & visual science. 42(12):2981-9 [PMID] 11687546.
View on: PubMed

Grants

Sep 2019 – Aug 2021
Optimization of food-grade recombinant probiotics for oral delivery of ACE2/Ang-(1-7)
Role: Co-Investigator
Funding: MEDOSOME BIOTEC via NATL INST OF HLTH NHLBI
Jun 2019 – May 2021
Fee for Service Contract with University of Alabama (UAB)
Role: Principal Investigator
Funding: UNIV OF ALABAMA BIRMINGHAM
May 2018 ACTIVE
ACE2 Modulates the Bone Marrow- Gut Axis in Diabetic Retinopathy
Role: Principal Investigator
Funding: UNIV OF ALABAMA BIRMINGHAM via NATL INST OF HLTH NEI
Aug 2016 ACTIVE
ACE2, Brain, Gut Dysbiosis in Pulmonary Hypertension
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2015 – Aug 2020
Oral therapy for diabetic retinopathy using ACE2/Ang1-7 bioencapsulated in plant cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NEI
Jul 2015 – Jun 2017
Ang-(1-7)/Mas Signaling in Aging Eye- Protective Mechanisms and Therapeutic Potential
Role: Principal Investigator
Funding: BRIGHTFOCUS FOU
Jan 2015 – Dec 2017
Oral delivery of bioencapsulated ACE2 and Ang1-7 for therapy of diabetic retinopathy
Role: Principal Investigator
Funding: AMER DIABETES ASSOCIATION
Jan 2012 – Dec 2016
Ocular Renin Angotensin System in Pathogenesis of Diabetic Retinopathy
Role: Principal Investigator
Funding: NATL INST OF HLTH NEI

Patents

Published April 2016
Oral Delivery of ACE2 For Chronic Diseases
#2016/0031816
Published February 2015
Delivery of NRF2 as Therapy for Protection Against Reactive Oxygen Species
#US2017/0088593
Published March 2014
Anti-Inflammatory AAV Vector Targeting Inflammasome Mediated Activation of Caspase-1
#US-2016-0017012
Published May 2010
Small Peptide Expression System in Mammalian Cells
#US-2012-0157513-A1

Teaching Profile

Courses Taught
2013-2015
GMS6417 Integrative Aging Physiology
2015
GMS6709 Current Topics in Vision
2015
GMS6683 Fundamentals of Vascular Physiology and Pathology
2013
PHA6971 Research for Master’s Thesis

Contact Details

Phones:
Business:
(352) 273-7540
Emails:
Business:
qli@ufl.edu