Ekaterina Lobanova

Ekaterina Lobanova, PhD

Assistant Professor

Department: MD-OPHTHALMOLOGY
Business Phone: (352) 273-8791
Business Email: elobanova@ufl.edu

About Ekaterina Lobanova

Dr. Lobanova received her BS in physics from the Lomonosov State University of Moscow, a top russian university. She continued her graduate studies at Biophysics Department with Prof. Fazly Ataullakhanov, using mathematical modeling to define unifying principles controlling complex behavior of biological systems. She then completed her postdoctoral training with Prof. Arshavsky at Harvard and Duke, where she sought to establish processes driving the pathobiology of retinal diseases.

Her current studies are focused on defining the mechanisms of protein and lipid processing in rod photoreceptors, the light-sensitive neurons of the eye.

Dr. Lobanova pioneered the concept of proteasomal overload as a common pathobiological factor shared between multiple forms of retinal degeneration. Building on these findings, she is developing novel approaches to manipulate proteasomal activity, which could be used in clinics to treat retinal diseases in a mutation-independent manner.

Photoreceptors detect light with their distinctive and large ciliated organelles, rod outer segments, which are tightly packed with lipid discs. These membranes are uniquely enriched with Omega-3 polyunsaturated fatty acids (PUFAs), more so than anywhere else in the body. Dr. Lobanova uses new genetic mouse models and sensitive lipidomics approaches to establish critical molecular components allowing photoreceptors to maintain the exceptional complexity of their membranes. Work in this direction can uncover novel therapeutic targets and design of lipid-based approaches to treat ocular diseases.

Publications

2021
Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4.
Journal of lipid research. 62 [DOI] 10.1016/j.jlr.2021.100030. [PMID] 33556440.
2020
Clarin-1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome.
The Journal of pathology. 250(2):195-204 [DOI] 10.1002/path.5360. [PMID] 31625146.
2020
Phosphoinositide Profile of the Mouse Retina.
Cells. 9(6) [DOI] 10.3390/cells9061417. [PMID] 32517352.
2020
Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity
Eneuro. 7(1) [DOI] 10.1523/ENEURO.0428-19.2019. [PMID] 31826915.
2020
Retinal homeostasis and metformin-induced protection are not affected by retina-specific Pparδ knockout.
Redox biology. 37 [DOI] 10.1016/j.redox.2020.101700. [PMID] 32863184.
2019
Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(49):9689-9701 [DOI] 10.1523/JNEUROSCI.1142-19.2019. [PMID] 31676603.
2019
Systemic Delivery of Genes to Retina Using Adeno-Associated Viruses.
Advances in experimental medicine and biology. 1185:109-112 [DOI] 10.1007/978-3-030-27378-1_18. [PMID] 31884597.
2018
C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis
The Journal of Neuroscience. 38(13):3160-3176 [DOI] 10.1523/JNEUROSCI.2964-17.2018. [PMID] 29440555.
2018
Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-04117-8. [PMID] 29712894.
2018
Transducin Beta-Subunit Can Interact With Multiple G-Protein Gamma-Subunits to Enable Light Detection By Rod Photoreceptors
Eneuro. 5(3):ENEURO.0144-18.2018 [DOI] 10.1523/ENEURO.0144-18.2018.
2017
Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.
PLoS genetics. 13(4) [DOI] 10.1371/journal.pgen.1006740. [PMID] 28410364.
2013
Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.
Proceedings of the National Academy of Sciences of the United States of America. 110(24):9986-91 [DOI] 10.1073/pnas.1305521110. [PMID] 23716657.
2010
Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa
Bmc Systems Biology. 4 [DOI] 10.1186/1752-0509-4-5. [PMID] 20102623.
2010
Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(20):6815-24 [DOI] 10.1523/JNEUROSCI.0613-10.2010. [PMID] 20484624.
2010
Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(9):3239-53 [DOI] 10.1523/JNEUROSCI.4775-09.2010. [PMID] 20203183.
2009
Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.
Biochemistry. 48(24):5563-72 [DOI] 10.1021/bi9000062. [PMID] 19438210.
2008
Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(13):3510-20 [DOI] 10.1523/JNEUROSCI.0338-08.2008. [PMID] 18367617.
2007
Transducin translocation in rods is triggered by saturation of the GTPase-activating complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(5):1151-60 [PMID] 17267570.
View on: PubMed
2006
Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.
Biochemistry. 45(38):11390-400 [PMID] 16981699.
View on: PubMed
2004
Complex dynamics of the formation of spatially localized standing structures in the vicinity of saddle-node bifurcations of waves in the reaction-diffusion model of blood clotting
Physical Review. E, Statistical, Nonlinear, And Soft Matter Physics. 70(3 Pt 1) [DOI] 10.1103/PhysRevE.70.032903. [PMID] 15524564.
2004
From nonequilibrium thermodynamics to nonlinear dynamics
Biofizika. 49(1):98-106 [PMID] 15029725.
View on: PubMed
2004
Running pulses of complex shape in a reaction-diffusion model
Physical Review Letters. 93(9) [DOI] 10.1103/PhysRevLett.93.098303. [PMID] 15447151.
2003
Unstable trigger waves induce various intricate dynamic regimes in a reaction-diffusion system of blood clotting
Physical Review Letters. 91(13) [DOI] 10.1103/PhysRevLett.91.138301. [PMID] 14525342.

Grants

Sep 2019 ACTIVE
Transcriptional control of proteostasis in photoreceptors
Role: Principal Investigator
Funding: NATL INST OF HLTH NEI

Teaching Profile

Courses Taught
2020-2021
GMS6791 Visual Neuroscience Journal Club

Contact Details

Phones:
Business:
(352) 273-8791
Emails:
Business:
elobanova@ufl.edu