James H Mcdowell

James H Mcdowell,

Scientist Emeritus

Department: MD-OPHTHALMOLOGY
Business Phone: (352) 273-8789
Business Email: jmcdowel@ufl.edu

Publications

2013
Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments.
Experimental eye research. 112:57-67 [DOI] 10.1016/j.exer.2013.04.006. [PMID] 23603319.
2013
Light-dependent phosphorylation of Bardet-Biedl syndrome 5 in photoreceptor cells modulates its interaction with arrestin1.
Cellular and molecular life sciences : CMLS. 70(23):4603-16 [DOI] 10.1007/s00018-013-1403-4. [PMID] 23817741.
2012
Aav-Mediated Gene Therapy in Mouse Models of Recessive Retinal Degeneration
Current Molecular Medicine. 12:316-330
2011
Interaction of arrestin with enolase1 in photoreceptors.
Investigative ophthalmology & visual science. 52(3):1832-40 [DOI] 10.1167/iovs.10-5724. [PMID] 21051714.
2011
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.
Journal of immunology (Baltimore, Md. : 1950). 187(4):1977-85 [DOI] 10.4049/jimmunol.1101247. [PMID] 21765017.
2008
A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin.
Investigative ophthalmology & visual science. 49(7):3224-30 [DOI] 10.1167/iovs.07-1539. [PMID] 18378578.
2006
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.
Molecular therapy : the journal of the American Society of Gene Therapy. 13(3):565-72 [PMID] 16223604.
View on: PubMed
2004
The surface of visual arrestin that binds to rhodopsin.
Molecular vision. 10:392-8 [PMID] 15215746.
View on: PubMed
2001
Activation of arrestin: requirement of phosphorylation as the negative charge on residues in synthetic peptides from the carboxyl-terminal region of rhodopsin.
Investigative ophthalmology & visual science. 42(7):1439-43 [PMID] 11381044.
View on: PubMed
1999
Identification of regions of arrestin that bind to rhodopsin.
Biochemistry. 38(9):2752-61 [PMID] 10052946.
View on: PubMed
1999
Sulfhydryl reactivity demonstrates different conformational states for arrestin, arrestin activated by a synthetic phosphopeptide, and constitutively active arrestin.
Biochemistry. 38(19):6119-25 [PMID] 10320338.
View on: PubMed

Contact Details

Phones:
Business:
(352) 273-8789
Emails:
Business:
jmcdowel@ufl.edu