Capsid mutations |
Cell tropism |
References |
|
AAV1 | RPE | Burger et al. | |
AAV2 | RPE, RGC | Acland et al.; Guy et al.1 | |
AAV2(444) | Y444F | RPE, RGC | Petrs-Silva et al.1 |
AAV2(double) | Y444F+Y730F | RPE, RGC | Petrs-Silva et al.2 |
AAV2(triple) | Y444F+Y500F+Y730F | RGC, PR | Petrs-Silva et al.2 |
AAV2(quad) | Y272F+Y444F+Y500F+Y730F | RGC, PR, VEC | Petrs-Silva et al.2; Cai et al. |
AAV2(sext) | Y252F+Y272F+Y444F+Y500F+Y704F+Y730F | Kidney | Petrs-Silva et al.2; Qi, YF et al. |
AAV2(sept) | Y252F+Y272F+Y444F+Y500F+Y700F+Y704F+Y730F | RGC, PR, VEC | Petrs-Silva et al.2; Ruan et al. |
AAV5 | PR, RPE, Cornea, Brain | Boye et al.1; Beltran et al.; Mohan et al.; Burger et al. | |
AAV5(719) | Y719F | PR, RPE | Michalakis et al. |
AAV8 | PR | Allocca et al. | |
AAV8(447) | Y447F | PR | Petrs-Silva et al.1 |
AAV8(733) | Y733F | PR, RPE | Petrs-Silva et al.1; Pang et al.; Boye et al.2, Deng et al. |
AAV9 | PR, Liver, Heart | Lebherz et al.; Sarkar et al. |