About Dr. Dinculescu

PRINCIPAL Investigator/assistant professor

Astra Dinculescu, PhD.

Dr. Dinculescu received her PhD in Biochemistry from University of Florida in 2002. Her main research focus is on developing therapeutic approaches for Usher syndrome type 3, an autosomal recessive disorder caused by mutations in Clarin-1 (CLRN1) gene, leading to progressive retinal degeneration and hearing loss. In addition, she studies the pathological processes affecting the retinal pigment epithelium (RPE)/Bruch’s membrane interface, and the mechanisms underlying the formation of drusen in age-related macular degeneration.

Photo Astra Dinculescu PhD

The Dinculesu Lab

See bottom of page for information on the individuals in our lab!

The Dinculescu lab team

areas of interest

Usher Syndrome

Age-Related Macular Degeneration (AMD)

Recombinant AAV-mediated Gene Therapy

Protein Aggregation

Retinal Pigment Epithelium

Extracellular Matrix Remodeling

Lab Staff

Doctoral Fellow

Lei Xu, PhD.

Lei Xu

Biological research scientist

Susan Bolch, PhD.

Scientist Emeritus

James Hugh McDowell, PhD.

James McDowell

Research tevhnician

Chiab Simpson